Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	1325
interventional	1023
Observational	280
Registry	22

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	388
Drug\|placebo	181
Other	120
Behavioral	86
Device	52
Dietary Supplement	42
Biological	26
Dietary Supplement\|placebo	26
Procedure	21
Drug\|Other	13
Drug\|Procedure	10
Device\|Drug	6
Device\|Other	6
Biological\|Drug	5
Biological\|placebo	4
Diagnostic Test	4
Dietary Supplement\|Drug\|placebo	4
Behavioral\|Dietary Supplement	3
Behavioral\|Other	2
Behavioral\|Procedure	2
Biological\|Drug\|placebo	2
Biological\|Procedure	2
Device\|Procedure	2
Dietary Supplement\|Drug	2
Drug\|placebo\|Procedure	2
Behavioral\|Device	1
Behavioral\|Drug\|Procedure	1
Biological\|Device\|Other	1
Biological\|Drug\|Other	1
Combination Product	1
Diagnostic Test\|Other	1
Dietary Supplement\|Drug\|Other	1
Dietary Supplement\|Other	1
Drug\|Other\|placebo	1
Other\|placebo	1
placebo\|Radiation	1
Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	354
NA	86
Japan	55
China	32
Canada	31
United Kingdom	31
France	30
Germany	27
Brazil	24
Korea, Republic of	22
Taiwan	18
United States\|Puerto Rico	18
Italy	17
Denmark	15
Netherlands	12
Belgium	11
Mexico	11
Spain	10
Turkey	9
Greece	6
Switzerland	6
Austria	5
Iran, Islamic Republic of	5
United States\|Canada	5
India	4
Israel	4
Russian Federation	4
Sweden	4
Australia	3
Hong Kong	3
Paraguay	3
Thailand	3
United States\|Japan	3
United States\|Poland	3
Argentina	2
Australia\|Bulgaria\|France\|Germany\|Hungary\|Israel\|Italy\|Japan\|Korea, Republic of\|Poland\|Romania\|Spain\|Turkey\|United Kingdom	2
Chile	2
Egypt	2
Ireland	2
Norway	2
Philippines	2
Poland	2
Argentina\|Australia\|Belgium\|Brazil\|Croatia\|Czechia\|France\|Germany\|Greece\|Israel\|Italy\|Korea, Republic of\|Lithuania\|Malaysia\|Mexico\|Panama\|Philippines\|Poland\|Russian Federation\|Serbia\|Singapore\|Spain\|Sweden\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
Argentina\|Chile\|Czechia\|Germany\|Hungary\|Poland\|Romania\|Russian Federation\|Turkey	1
Argentina\|Paraguay	1
Argentina\|United States\|Australia\|Brazil\|Bulgaria\|France\|Hungary\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|New Zealand\|Poland\|Puerto Rico\|Russian Federation\|South Africa\|Spain\|Ukraine\|United Kingdom	1
Armenia\|Georgia\|Moldova, Republic of	1
Australia\|Austria\|Czech Republic\|France\|Germany\|Hungary\|Italy\|Poland\|South Africa\|Spain\|United Kingdom	1
Australia\|Belgium\|Bulgaria\|Czech Republic\|Denmark\|Estonia\|France\|Germany\|Greece\|Hungary\|Israel\|Italy\|Latvia\|Mexico\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Slovakia\|Slovenia\|Spain\|United Kingdom	1
Australia\|Belgium\|Canada\|France\|Germany\|Greece\|Hong Kong\|Hungary\|Israel\|Italy\|Korea, Republic of\|Poland\|Russian Federation\|Spain\|Taiwan\|Thailand	1
Australia\|Belgium\|France\|Germany\|Hungary\|Italy\|Poland\|Romania\|Russian Federation\|Spain\|Thailand\|Ukraine	1
Australia\|Canada\|New Zealand	1
Australia\|Denmark\|France\|Germany\|United Kingdom	1
Austria\|Belarus\|Bulgaria\|Croatia\|Czechia\|Finland\|France\|Georgia\|Germany\|Hungary\|Ireland\|Israel\|Latvia\|Montenegro\|Netherlands\|North Macedonia\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Slovakia\|Slovenia\|Spain\|Ukraine\|United Kingdom	1
Austria\|Belgium\|Czech Republic\|Denmark\|Finland\|Germany\|Israel\|Norway\|Poland\|Sweden	1
Austria\|Bulgaria\|France\|Germany\|Italy\|Macedonia, The Former Yugoslav Republic of\|Poland\|Romania\|Russian Federation\|Ukraine	1
Austria\|Czech Republic\|France\|Germany\|Hungary\|Italy\|Macedonia, The Former Yugoslav Republic of\|Malaysia\|Poland\|Russian Federation\|Serbia\|South Africa\|Spain\|Ukraine\|United Kingdom	1
Bangladesh	1
Belarus\|Belgium\|Bulgaria\|Colombia\|Dominican Republic\|Estonia\|Georgia\|Greece\|Guatemala\|Hungary\|Italy\|Panama\|Peru\|Poland\|Romania\|Russian Federation\|Serbia\|South Africa\|Spain\|Turkey\|Ukraine\|United Kingdom	1
Belarus\|Bulgaria\|Croatia\|Denmark\|Indonesia\|Israel\|Italy\|Latvia\|Lithuania\|Malaysia\|Romania\|Singapore\|Thailand	1
Belgium\|Canada\|France\|Netherlands\|Poland\|Spain\|United Kingdom	1
Belgium\|Czechia\|Denmark\|Finland\|France\|Germany\|Greece\|Italy\|Romania\|Russian Federation\|Slovakia\|Spain\|Ukraine\|United Kingdom	1
Belgium\|Denmark\|France\|Italy\|Netherlands\|Spain\|United Kingdom	1
Belgium\|Italy	1
Belgium\|United States\|Albania\|Argentina\|Australia\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Czechia\|France\|Georgia\|Hong Kong\|Hungary\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|New Zealand\|North Macedonia\|Poland\|Portugal\|Romania\|Serbia\|Singapore\|Slovakia\|Spain\|Taiwan\|Ukraine\|United Kingdom	1
Belgium\|United States\|Argentina\|Australia\|Canada\|Czechia\|Denmark\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|Norway\|Poland\|Puerto Rico\|Romania\|Russian Federation\|South Africa\|Spain\|Sweden\|United Kingdom	1
Bulgaria\|Georgia	1
Bulgaria\|Moldova, Republic of\|Romania	1
Bulgaria\|Romania\|United Kingdom	1
Bulgaria\|South Africa	1
Canada\|Germany\|United Kingdom	1
Canada\|Malaysia\|Netherlands	1
Canada\|United States\|Australia\|Austria\|Bulgaria\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Greece\|Hungary\|Israel\|Italy\|Korea, Republic of\|Lithuania\|Netherlands\|Norway\|Poland\|Portugal\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey	1
China\|Hong Kong	1
China\|Hong Kong\|India\|Korea, Republic of\|Malaysia\|Taiwan	1
China\|Hong Kong\|Japan\|Korea, Republic of\|Malaysia\|Taiwan\|Thailand	1
Colombia\|Finland\|Germany\|Guatemala\|Korea, Republic of\|Philippines\|Poland\|Romania\|Russian Federation\|Singapore	1
Croatia\|Georgia\|Hungary\|Serbia\|Slovenia	1
Croatia\|United States\|Austria\|Belgium\|Czech Republic\|Germany\|Latvia\|Lithuania\|Poland\|Romania\|Russian Federation\|Serbia\|South Africa\|Ukraine\|United Kingdom	1
Czech Republic	1
Czech Republic\|France\|Germany\|Hungary\|Italy\|Lithuania\|Poland\|Portugal\|Serbia\|Sweden\|Switzerland\|Turkey	1
Czechia	1
Czechia\|Denmark\|Germany\|Hungary\|Italy\|Netherlands\|Poland\|Spain\|United Kingdom	1
Czechia\|Germany	1
Czechia\|Hungary	1
Denmark\|Germany\|Hong Kong\|Israel\|Poland\|Singapore\|Sweden\|Switzerland\|United Kingdom	1
Finland	1
France\|Germany\|United Kingdom	1
France\|United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|Czechia\|Denmark\|Estonia\|Germany\|Greece\|Hungary\|India\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Norway\|Poland\|Portugal\|Romania\|Russian Federation\|Singapore\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
France\|United States\|Australia\|Austria\|Belgium\|Canada\|Czechia\|Denmark\|Germany\|Greece\|Hungary\|Israel\|Italy\|Latvia\|Lithuania\|Netherlands\|New Zealand\|Poland\|Portugal\|Russian Federation\|Spain\|Sweden\|Switzerland\|Turkey	1
Georgia\|Slovenia	1
Germany\|United Kingdom	1
Greece\|Slovenia	1
Hungary\|Australia\|Bulgaria\|France\|Germany\|Israel\|Italy\|Japan\|Korea, Republic of\|Poland\|Romania\|Spain\|Turkey\|United Kingdom	1
Hungary\|Italy\|Macedonia, The Former Yugoslav Republic of\|Malaysia\|Poland\|Russian Federation\|Serbia\|Ukraine	1
Hungary\|United States\|China\|Czechia\|France\|Israel\|Italy\|Mexico\|Poland\|Romania\|Slovakia\|South Africa\|Spain	1
Indonesia	1
Japan\|Taiwan	1
Malaysia	1
Moldova, Republic of\|Romania	1
New Zealand	1
Peru	1
Poland\|United Kingdom	1
Portugal\|Spain	1
Romania	1
Russian Federation\|Germany\|Italy\|Poland\|Romania\|Turkey\|Ukraine	1
Serbia	1
Serbia\|United States\|Bulgaria\|Croatia\|Georgia\|Hungary\|Slovenia\|Ukraine	1
Singapore	1
Slovakia	1
Sweden\|Australia\|France\|Italy\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Chile\|Colombia\|Croatia\|Czechia\|Egypt\|France\|Germany\|Greece\|India\|Israel\|Italy\|Japan\|Korea, Republic of\|Kuwait\|Lebanon\|Malaysia\|Mexico\|Netherlands\|Norway\|Philippines\|Poland\|Portugal\|Russian Federation\|Saudi Arabia\|Serbia\|Singapore\|Slovakia\|Slovenia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey	1
United States\|Argentina\|Australia\|Austria\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Czechia\|France\|Germany\|Hungary\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|New Zealand\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|China\|France\|Germany\|Greece\|Hungary\|India\|Israel\|Italy\|Japan\|Malaysia\|Mexico\|Netherlands\|Poland\|Russian Federation\|Slovakia\|South Africa\|Spain\|Thailand\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|Colombia\|Czechia\|Denmark\|Estonia\|France\|Germany\|Greece\|Hong Kong\|Hungary\|India\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Philippines\|Poland\|Portugal\|Romania\|Russian Federation\|Singapore\|South Africa\|Spain\|Sweden\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom\|Vietnam	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|Peru\|Chile\|China\|Czechia\|Denmark\|Estonia\|France\|Georgia\|Germany\|Greece\|Guatemala\|Hungary\|India\|Israel\|Italy\|Korea, Republic of\|Latvia\|Lithuania\|Mexico\|Netherlands\|New Zealand\|North Macedonia\|Norway\|Poland\|Portugal\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Bulgaria\|Canada\|France\|Germany\|Israel\|Italy\|Korea, Republic of\|Mexico\|Poland\|Portugal\|Russian Federation\|Serbia\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Canada\|France\|Italy\|Korea, Republic of\|Mexico\|Poland\|Romania\|Russian Federation\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Canada\|France\|Italy\|Korea, Republic of\|Poland\|Romania\|Russian Federation\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Canada\|Germany\|India\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Poland\|Russian Federation\|South Africa\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Chile\|Colombia\|Hong Kong\|Korea, Republic of\|Malaysia\|Mexico\|New Zealand\|Peru\|Philippines\|Puerto Rico\|Singapore\|Taiwan\|Thailand	1
United States\|Argentina\|Brazil\|Bulgaria\|Canada\|Colombia\|Czechia\|Germany\|Hungary\|India\|Korea, Republic of\|Malaysia\|Mexico\|Peru\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Slovakia\|Spain\|Taiwan\|Thailand\|Turkey\|Ukraine\|Vietnam	1
United States\|Argentina\|Brazil\|Canada\|China\|Denmark\|Germany\|Hungary\|India\|Japan\|Korea, Republic of\|Mexico\|Peru\|Philippines\|Poland\|Russian Federation\|Spain\|Sweden\|Ukraine\|United Kingdom\|Vietnam	1
United States\|Argentina\|Brazil\|Canada\|Colombia\|Germany\|Hungary\|Israel\|Italy\|Mexico\|Poland\|Romania\|Russian Federation\|South Africa\|Spain\|Ukraine	1
United States\|Argentina\|Brazil\|Canada\|Czech Republic\|France\|Italy\|Mexico\|Poland\|Puerto Rico\|Russian Federation\|Ukraine	1
United States\|Argentina\|Brazil\|Canada\|Czech Republic\|Germany\|Mexico\|Poland\|Puerto Rico\|Russian Federation\|Spain\|Ukraine	1
United States\|Argentina\|Brazil\|Colombia\|Germany\|Hungary\|Israel\|Italy\|Mexico\|Poland\|Romania\|Russian Federation\|South Africa\|Spain\|Ukraine	1
United States\|Argentina\|Brazil\|Germany\|Italy\|Korea, Republic of\|Mexico\|Poland\|Portugal\|Russian Federation\|Ukraine	1
United States\|Argentina\|India\|Korea, Republic of\|Malaysia\|Russian Federation\|Singapore\|Taiwan\|Turkey	1
United States\|Australia\|Austria\|Belgium\|Canada\|Czechia\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|Poland\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|Czechia\|France\|Germany\|Hungary\|Israel\|Italy\|Poland\|Russian Federation\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Poland\|Spain\|Switzerland	1
United States\|Australia\|Austria\|Belgium\|Czech Republic\|Denmark\|France\|Germany\|Greece\|Italy\|Netherlands\|Norway\|Poland\|Portugal\|Romania\|Spain\|Sweden\|Turkey\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Czech Republic\|France\|Germany\|Hungary\|Israel\|Italy\|Poland\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Czechia\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|Poland\|Russian Federation\|Spain\|Sweden	1
United States\|Australia\|Belgium\|Canada\|Finland\|France\|Germany\|Italy\|Norway\|Puerto Rico\|Sweden\|Switzerland\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|France\|Germany\|Greece\|Italy\|Netherlands\|Puerto Rico\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Canada\|Czechia\|Denmark\|France\|Germany\|Hungary\|Japan\|Korea, Republic of\|Norway\|Poland\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Canada\|Czechia\|Denmark\|France\|Germany\|Hungary\|Japan\|Korea, Republic of\|Poland\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Czech Republic\|Germany\|Italy\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Spain\|Taiwan\|United Kingdom	1
United States\|Australia\|Hong Kong\|Israel\|New Zealand\|Ukraine	1
United States\|Austria\|Belgium\|Canada\|Czechia\|Denmark\|Estonia\|France\|Germany\|Greece\|Hungary\|Italy\|Latvia\|Lithuania\|New Zealand\|Poland\|Portugal\|Russian Federation\|Spain\|Sweden\|Switzerland\|Turkey	1
United States\|Austria\|Belgium\|Croatia\|Czech Republic\|Germany\|Latvia\|Lithuania\|Poland\|Romania\|Russian Federation\|Serbia\|South Africa\|Ukraine\|United Kingdom	1
United States\|Belgium\|Canada\|Germany\|India\|Poland\|United Kingdom	1
United States\|Belgium\|Czechia\|France\|Germany\|Greece\|Hungary\|Italy\|Poland\|Russian Federation\|Ukraine	1
United States\|Belgium\|Germany\|Lithuania\|Poland\|United Kingdom	1
United States\|Brazil\|Canada	1
United States\|Brazil\|Hungary\|Mexico\|Poland\|Romania\|South Africa\|Spain\|Ukraine	1
United States\|Bulgaria\|Canada\|Georgia\|Germany\|Poland\|Ukraine	1
United States\|Bulgaria\|Croatia\|Czech Republic\|Germany\|Poland\|Romania\|Russian Federation\|Switzerland	1
United States\|Bulgaria\|Croatia\|Georgia\|Germany\|Hungary\|South Africa\|Ukraine\|United Kingdom	1
United States\|Bulgaria\|Czech Republic\|Germany\|Hungary\|Italy\|Poland\|Puerto Rico\|Romania\|United Kingdom	1
United States\|Bulgaria\|Czechia\|Hungary\|Poland\|Romania\|South Africa\|Spain	1
United States\|Bulgaria\|France\|Germany\|Italy\|Poland\|Romania\|Spain\|United Kingdom	1
United States\|Canada\|China\|Germany\|Japan\|Malaysia\|United Kingdom	1
United States\|Canada\|Denmark\|Germany\|Norway\|Sweden	1
United States\|Canada\|Germany	1
United States\|Canada\|Germany\|Russian Federation\|Spain	1
United States\|Canada\|Puerto Rico\|Taiwan	1
United States\|Canada\|United Kingdom	1
United States\|Cayman Islands	1
United States\|Chile	1
United States\|Croatia\|Czech Republic\|Denmark\|Georgia\|Hungary\|Italy\|Serbia\|Slovenia\|Ukraine	1
United States\|Czech Republic\|Denmark\|Germany\|Greece\|Italy\|Netherlands\|Portugal\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|France\|Germany\|Hungary\|Italy\|Lithuania\|Poland\|Spain	1
United States\|France\|Germany\|Lithuania\|Poland	1
United States\|France\|Spain\|United Kingdom	1
United States\|Germany	1
United States\|Germany\|Greece\|Italy\|Netherlands\|Poland\|Portugal\|Puerto Rico\|Spain\|Taiwan	1
United States\|Germany\|Puerto Rico\|United Kingdom	1
United States\|Germany\|United Kingdom	1
United States\|Guatemala	1
United States\|Hungary\|Lithuania\|Mexico\|Poland	1
United States\|United Kingdom	1
Vietnam	1

Sites per Study

Site_count	Study_Count
1	626
2	68
3	24
4	26
5	17
6	7
7	11
8	5
9	5
10	6
11	10
12	9
13	6
14	5
15	9
16	4
17	3
18	7
19	5
20	6
21	6
22	2
23	1
24	2
25	3
26	4
27	2
28	7
29	1
30	4
31	4
32	3
33	4
34	2
35	2
36	4
37	1
38	4
39	4
40	3
41	2
42	1
43	2
44	2
45	3
47	2
49	2
50	2
51	2
52	2
53	4
55	2
56	1
57	2
58	1
59	1
60	2
61	1
62	2
64	1
66	2
68	1
69	1
71	1
72	3
73	3
76	1
83	1
84	1
85	1
89	2
90	2
91	2
98	1
105	2
106	3
107	1
110	1
114	2
115	2
118	2
123	1
124	1
125	1
138	1
141	1
145	1
157	1
169	1
170	1
183	1
184	1
192	1
196	1
203	1
209	1
229	1
231	1
239	1
249	1
278	1
342	1
360	1
381	1
398	1
439	1
465	1
503	1
602	1
754	1

Phase

Phase	Study_Count
N/A	363
Phase 3	218
Phase 2	166
Phase 4	156
Phase 1	78
Phase 1/Phase 2	20
Phase 2/Phase 3	16
Early Phase 1	6

Number of Arms

Number_of_Arms	Count_of_Studies
1	178
2	584
3	102
4	65
5	19
6	17
7	7
8	4
13	1
NA	46

Number of Updates

Count of Versions	Count of Studies
1	96
2	123
3	121
4	134
5	91
6	75
7	43
8	45
9	45
10	30
11	20
12	13
13	12
14	11
15	13
16	9
17	11
18	8
19	8
20	7
21	11
22	6
23	10
24	2
25	5
26	1
27	3
28	3
29	2
30	5
31	2
32	2
33	3
34	5
35	1
36	1
37	5
38	1
39	1
42	2
43	2
44	2
45	1
46	1
47	2
50	1
51	1
52	1
53	1
54	2
57	1
62	1
63	1
64	2
69	1
70	1
71	1
73	1
77	1
78	1
80	1
83	1
91	1
92	1
95	1
97	1
116	1
119	1
120	2
135	1
139	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	8750	927	9.439051
Contacts/Locations	4662	813	5.734317
Recruitment Status	1544	809	1.908529
Study Design	1133	723	1.567082
None (earliest Version on record)	1023	1023	1.000000
Outcome Measures	871	499	1.745491
Eligibility	755	417	1.810552
Arms	640	391	1.636829
Interventions	640	391	1.636829
Study Description	595	338	1.760355
Sponsor/Collaborators	567	391	1.450128
Study Identification	534	344	1.552326
Oversight	354	279	1.268817
References	305	180	1.694444
More Information	291	145	2.006897
Conditions	261	172	1.517442
Results	185	185	1.000000
IPDSharing	163	125	1.304000
Baseline Characteristics	104	92	1.130435
Reported Adverse Events	87	74	1.175676
Participant Flow	76	69	1.101449
Results Submission Events	71	71	1.000000
Documents	61	52	1.173077
2020 Outcome Measures	1	1	1.000000
2020 Study Status	1	1	1.000000
Quality Control Review has not concludedReturned: February 10	1	1	1.000000
Quality Control Review has not concludedReturned: March 17	1	1	1.000000

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	5.00000	3.0000	5.00000	8.00	1.0000	15.0000	4.0000	2.0000
1st Qu.	12.00000	32.0000	15.25000	21.50	47.2500	36.7500	104.0000	34.0000
Median	21.00000	60.0000	27.00000	33.50	91.0000	61.5000	234.0000	78.0000
Mean	23.16667	471.1536	35.46154	90.55	118.3494	384.8125	657.5853	434.4167
3rd Qu.	37.50000	149.5000	40.00000	61.50	152.5000	163.7500	468.0000	200.2500
Max.	40.00000	28304.0000	205.00000	1000.00	1058.0000	4110.0000	25210.0000	21983.0000

Trial Group Type

group_type	Group_Count
Experimental	1134
Active Comparator	548
Placebo Comparator	246
No Intervention	152
Other	111
NA	46
Sham Comparator	12

Intervention Model

intervention_model	Study_Count
Parallel Assignment	654
Single Group Assignment	220
Crossover Assignment	118
Factorial Assignment	20
Sequential Assignment	9
NA	2

Primary Purpose

primary_purpose	Study_Count
Treatment	708
Prevention	100
Supportive Care	48
Health Services Research	36
Basic Science	35
Other	35
Diagnostic	26
NA	23
Screening	10
Device Feasibility	2

Observational Studies

Studies by Country

Country	Study_Count
United States	63
NA	29
United Kingdom	27
France	17
China	13
Germany	13
Belgium	10
Canada	7
Korea, Republic of	7
Austria	6
Denmark	6
Japan	5
Sweden	5
Turkey	5
Israel	4
Russian Federation	4
Spain	4
Greece	3
Italy	3
Netherlands	3
Taiwan	3
Brazil	2
Hungary	2
Macedonia, The Former Yugoslav Republic of	2
Romania	2
Singapore	2
Thailand	2
Albania	1
Argentina\|Belgium\|Czechia\|Denmark\|Finland\|France\|Germany\|Hungary\|Ireland\|Israel\|Italy\|Lithuania\|Luxembourg\|Netherlands\|Norway\|Russian Federation\|Saudi Arabia\|Serbia\|Slovenia\|Spain\|Sweden\|Switzerland\|United Kingdom	1
Australia	1
Australia\|United Kingdom	1
Austria\|Denmark\|France\|Germany\|Italy\|Netherlands\|Spain	1
Austria\|Germany	1
Austria\|Germany\|Israel\|Italy\|Netherlands\|Poland\|Spain	1
Austria\|Italy\|Netherlands\|Spain	1
Belarus	1
Brazil\|France\|Norway\|South Africa\|Sweden\|Thailand\|United Kingdom	1
Bulgaria\|Czech Republic\|Romania	1
Chile	1
Croatia	1
Croatia\|Serbia	1
Czechia	1
Egypt	1
Germany\|India\|Sri Lanka	1
Hong Kong	1
Pakistan	1
Poland\|Austria\|Bulgaria\|Czech Republic\|Greece\|Hungary\|Italy\|Spain	1
Poland\|Austria\|France\|Germany\|Italy\|Romania\|Slovenia\|Spain\|Switzerland\|United Kingdom	1
Portugal	1
Slovenia	1
South Africa	1
Sweden\|United Kingdom	1
Switzerland	1
United States\|Canada	1
United States\|Canada\|Israel\|Singapore\|United Kingdom	1
United States\|Germany	1
United States\|Italy\|Sweden\|United Kingdom	1
United States\|Puerto Rico	1

Sites per Study

Site_count	Study_Count
1	205
2	22
3	8
4	3
5	2
6	3
7	1
8	2
9	1
10	3
11	1
12	4
13	4
14	2
16	1
17	1
18	2
19	1
21	1
22	1
23	1
24	1
26	1
29	1
32	1
40	1
41	1
52	1
69	1
87	1
95	1
108	1

Number of Updates

Count of Versions	Count of Studies
1	50
2	43
3	42
4	26
5	27
6	21
7	9
8	6
9	8
10	8
11	5
12	6
13	2
14	1
15	1
16	1
17	4
18	2
21	1
22	2
24	2
28	1
30	1
31	2
37	2
39	1
53	1
54	2
56	1
59	1
79	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	1609	230	6.995652
Contacts/Locations	512	189	2.708995
Recruitment Status	303	184	1.646739
None (earliest Version on record)	280	280	1.000000
Study Design	235	150	1.566667
Study Description	157	95	1.652632
Sponsor/Collaborators	144	95	1.515789
Eligibility	120	82	1.463415
Outcome Measures	115	90	1.277778
Study Identification	100	65	1.538461
Groups	99	77	1.285714
Interventions	99	77	1.285714
Conditions	56	35	1.600000
Oversight	55	50	1.100000
References	47	26	1.807692
Results	29	29	1.000000
IPDSharing	22	19	1.157895
More Information	22	17	1.294118
Baseline Characteristics	4	4	1.000000
Results Submission Events	4	4	1.000000
Documents	3	2	1.500000
Reported Adverse Events	2	2	1.000000
Participant Flow	1	1	1.000000

Enrollment Metrics

Measure	Observational
Min	1.000
1st Qu	65.000
Median	181.000
Mean	9038.487
3rd Qu	734.500
Max	1800000.000

Observation Model

observational_model	Study_Count
Cohort	177
Case-Only	26
Case-Control	18
Case Control	18
NA	18
Other	14
Case-Crossover	4
Natural History	2
Defined Population	1
Ecologic or Community	1
Family-Based	1

Time Perspective

time_perspective	Study_Count
Prospective	185
Cross-Sectional	49
Retrospective	30
Other	7
NA	6
Longitudinal, Retrospective	2
Longitudinal, Prospective	1

Registries

Studies by Country

Country	Study_Count
United States	6
NA	4
Taiwan	2
Australia\|Germany\|United Kingdom	1
Austria	1
Austria\|Belgium\|France\|Germany\|Switzerland	1
China	1
Germany	1
India	1
Pakistan	1
Spain	1
Sweden	1
United Kingdom	1

Sites per Study

Site_count	Study_Count
1	13
2	1
4	2
9	1
12	1
14	1
18	1
20	1
125	1

Number of Updates

Count of Versions	Count of Studies
1	6
2	1
3	4
4	2
5	1
6	1
7	1
8	1
9	1
11	2
12	1
31	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	106	16	6.625000
Contacts/Locations	59	11	5.363636
None (earliest Version on record)	22	22	1.000000
Recruitment Status	17	11	1.545454
Study Design	10	7	1.428571
Outcome Measures	9	6	1.500000
Eligibility	8	8	1.000000
Sponsor/Collaborators	6	5	1.200000
Study Identification	6	5	1.200000
Study Description	5	5	1.000000
Groups	4	4	1.000000
Interventions	4	4	1.000000
IPDSharing	3	3	1.000000
Oversight	3	3	1.000000
References	3	3	1.000000
Conditions	2	2	1.000000
More Information	1	1	1.000000
Reported Adverse Events	1	1	1.000000
Results	1	1	1.000000

Enrollment Metrics

Measure	Registries
Min	30.0
1st Qu	212.5
Median	360.5
Mean	318312.0
3rd Qu	2522.5
Max	5940299.0

Registry Model

observational_model	Study_Count
Cohort	14
Case-Control	3
Other	2
NA	2
Case-Only	1

Time Perspective

time_perspective	Study_Count
Prospective	16
Cross-Sectional	5
NA	1

Follow-up

target_duration	Study_Count
1 Day	5
2 Years	4
5 Years	4
1 Year	1
12 Months	1
17 Years	1
18 Months	1
2 Months	1
2 Weeks	1
20 Years	1
24 Months	1
3 Years	1

intervention_type	Study_Count
Drug	388
Drug\|placebo	181
Other	120
Behavioral	86
Device	52
Dietary Supplement	42
Biological	26
Dietary Supplement\|placebo	26
Procedure	21
Drug\|Other	13
Drug\|Procedure	10
Device\|Drug	6
Device\|Other	6
Biological\|Drug	5
Biological\|placebo	4
Diagnostic Test	4
Dietary Supplement\|Drug\|placebo	4
Behavioral\|Dietary Supplement	3
Behavioral\|Other	2
Behavioral\|Procedure	2
Biological\|Drug\|placebo	2
Biological\|Procedure	2
Device\|Procedure	2
Dietary Supplement\|Drug	2
Drug\|placebo\|Procedure	2
Behavioral\|Device	1
Behavioral\|Drug\|Procedure	1
Biological\|Device\|Other	1
Biological\|Drug\|Other	1
Combination Product	1
Diagnostic Test\|Other	1
Dietary Supplement\|Drug\|Other	1
Dietary Supplement\|Other	1
Drug\|Other\|placebo	1
Other\|placebo	1
placebo\|Radiation	1
Radiation	1

Country	Study_Count
United States	354
NA	86
Japan	55
China	32
Canada	31
United Kingdom	31
France	30
Germany	27
Brazil	24
Korea, Republic of	22
Taiwan	18
United States\|Puerto Rico	18
Italy	17
Denmark	15
Netherlands	12
Belgium	11
Mexico	11
Spain	10
Turkey	9
Greece	6
Switzerland	6
Austria	5
Iran, Islamic Republic of	5
United States\|Canada	5
India	4
Israel	4
Russian Federation	4
Sweden	4
Australia	3
Hong Kong	3
Paraguay	3
Thailand	3
United States\|Japan	3
United States\|Poland	3
Argentina	2
Australia\|Bulgaria\|France\|Germany\|Hungary\|Israel\|Italy\|Japan\|Korea, Republic of\|Poland\|Romania\|Spain\|Turkey\|United Kingdom	2
Chile	2
Egypt	2
Ireland	2
Norway	2
Philippines	2
Poland	2
Argentina\|Australia\|Belgium\|Brazil\|Croatia\|Czechia\|France\|Germany\|Greece\|Israel\|Italy\|Korea, Republic of\|Lithuania\|Malaysia\|Mexico\|Panama\|Philippines\|Poland\|Russian Federation\|Serbia\|Singapore\|Spain\|Sweden\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
Argentina\|Chile\|Czechia\|Germany\|Hungary\|Poland\|Romania\|Russian Federation\|Turkey	1
Argentina\|Paraguay	1
Argentina\|United States\|Australia\|Brazil\|Bulgaria\|France\|Hungary\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|New Zealand\|Poland\|Puerto Rico\|Russian Federation\|South Africa\|Spain\|Ukraine\|United Kingdom	1
Armenia\|Georgia\|Moldova, Republic of	1
Australia\|Austria\|Czech Republic\|France\|Germany\|Hungary\|Italy\|Poland\|South Africa\|Spain\|United Kingdom	1
Australia\|Belgium\|Bulgaria\|Czech Republic\|Denmark\|Estonia\|France\|Germany\|Greece\|Hungary\|Israel\|Italy\|Latvia\|Mexico\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Slovakia\|Slovenia\|Spain\|United Kingdom	1
Australia\|Belgium\|Canada\|France\|Germany\|Greece\|Hong Kong\|Hungary\|Israel\|Italy\|Korea, Republic of\|Poland\|Russian Federation\|Spain\|Taiwan\|Thailand	1
Australia\|Belgium\|France\|Germany\|Hungary\|Italy\|Poland\|Romania\|Russian Federation\|Spain\|Thailand\|Ukraine	1
Australia\|Canada\|New Zealand	1
Australia\|Denmark\|France\|Germany\|United Kingdom	1
Austria\|Belarus\|Bulgaria\|Croatia\|Czechia\|Finland\|France\|Georgia\|Germany\|Hungary\|Ireland\|Israel\|Latvia\|Montenegro\|Netherlands\|North Macedonia\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Slovakia\|Slovenia\|Spain\|Ukraine\|United Kingdom	1
Austria\|Belgium\|Czech Republic\|Denmark\|Finland\|Germany\|Israel\|Norway\|Poland\|Sweden	1
Austria\|Bulgaria\|France\|Germany\|Italy\|Macedonia, The Former Yugoslav Republic of\|Poland\|Romania\|Russian Federation\|Ukraine	1
Austria\|Czech Republic\|France\|Germany\|Hungary\|Italy\|Macedonia, The Former Yugoslav Republic of\|Malaysia\|Poland\|Russian Federation\|Serbia\|South Africa\|Spain\|Ukraine\|United Kingdom	1
Bangladesh	1
Belarus\|Belgium\|Bulgaria\|Colombia\|Dominican Republic\|Estonia\|Georgia\|Greece\|Guatemala\|Hungary\|Italy\|Panama\|Peru\|Poland\|Romania\|Russian Federation\|Serbia\|South Africa\|Spain\|Turkey\|Ukraine\|United Kingdom	1
Belarus\|Bulgaria\|Croatia\|Denmark\|Indonesia\|Israel\|Italy\|Latvia\|Lithuania\|Malaysia\|Romania\|Singapore\|Thailand	1
Belgium\|Canada\|France\|Netherlands\|Poland\|Spain\|United Kingdom	1
Belgium\|Czechia\|Denmark\|Finland\|France\|Germany\|Greece\|Italy\|Romania\|Russian Federation\|Slovakia\|Spain\|Ukraine\|United Kingdom	1
Belgium\|Denmark\|France\|Italy\|Netherlands\|Spain\|United Kingdom	1
Belgium\|Italy	1
Belgium\|United States\|Albania\|Argentina\|Australia\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Czechia\|France\|Georgia\|Hong Kong\|Hungary\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|New Zealand\|North Macedonia\|Poland\|Portugal\|Romania\|Serbia\|Singapore\|Slovakia\|Spain\|Taiwan\|Ukraine\|United Kingdom	1
Belgium\|United States\|Argentina\|Australia\|Canada\|Czechia\|Denmark\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|Norway\|Poland\|Puerto Rico\|Romania\|Russian Federation\|South Africa\|Spain\|Sweden\|United Kingdom	1
Bulgaria\|Georgia	1
Bulgaria\|Moldova, Republic of\|Romania	1
Bulgaria\|Romania\|United Kingdom	1
Bulgaria\|South Africa	1
Canada\|Germany\|United Kingdom	1
Canada\|Malaysia\|Netherlands	1
Canada\|United States\|Australia\|Austria\|Bulgaria\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Greece\|Hungary\|Israel\|Italy\|Korea, Republic of\|Lithuania\|Netherlands\|Norway\|Poland\|Portugal\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey	1
China\|Hong Kong	1
China\|Hong Kong\|India\|Korea, Republic of\|Malaysia\|Taiwan	1
China\|Hong Kong\|Japan\|Korea, Republic of\|Malaysia\|Taiwan\|Thailand	1
Colombia\|Finland\|Germany\|Guatemala\|Korea, Republic of\|Philippines\|Poland\|Romania\|Russian Federation\|Singapore	1
Croatia\|Georgia\|Hungary\|Serbia\|Slovenia	1
Croatia\|United States\|Austria\|Belgium\|Czech Republic\|Germany\|Latvia\|Lithuania\|Poland\|Romania\|Russian Federation\|Serbia\|South Africa\|Ukraine\|United Kingdom	1
Czech Republic	1
Czech Republic\|France\|Germany\|Hungary\|Italy\|Lithuania\|Poland\|Portugal\|Serbia\|Sweden\|Switzerland\|Turkey	1
Czechia	1
Czechia\|Denmark\|Germany\|Hungary\|Italy\|Netherlands\|Poland\|Spain\|United Kingdom	1
Czechia\|Germany	1
Czechia\|Hungary	1
Denmark\|Germany\|Hong Kong\|Israel\|Poland\|Singapore\|Sweden\|Switzerland\|United Kingdom	1
Finland	1
France\|Germany\|United Kingdom	1
France\|United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|Czechia\|Denmark\|Estonia\|Germany\|Greece\|Hungary\|India\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Norway\|Poland\|Portugal\|Romania\|Russian Federation\|Singapore\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
France\|United States\|Australia\|Austria\|Belgium\|Canada\|Czechia\|Denmark\|Germany\|Greece\|Hungary\|Israel\|Italy\|Latvia\|Lithuania\|Netherlands\|New Zealand\|Poland\|Portugal\|Russian Federation\|Spain\|Sweden\|Switzerland\|Turkey	1
Georgia\|Slovenia	1
Germany\|United Kingdom	1
Greece\|Slovenia	1
Hungary\|Australia\|Bulgaria\|France\|Germany\|Israel\|Italy\|Japan\|Korea, Republic of\|Poland\|Romania\|Spain\|Turkey\|United Kingdom	1
Hungary\|Italy\|Macedonia, The Former Yugoslav Republic of\|Malaysia\|Poland\|Russian Federation\|Serbia\|Ukraine	1
Hungary\|United States\|China\|Czechia\|France\|Israel\|Italy\|Mexico\|Poland\|Romania\|Slovakia\|South Africa\|Spain	1
Indonesia	1
Japan\|Taiwan	1
Malaysia	1
Moldova, Republic of\|Romania	1
New Zealand	1
Peru	1
Poland\|United Kingdom	1
Portugal\|Spain	1
Romania	1
Russian Federation\|Germany\|Italy\|Poland\|Romania\|Turkey\|Ukraine	1
Serbia	1
Serbia\|United States\|Bulgaria\|Croatia\|Georgia\|Hungary\|Slovenia\|Ukraine	1
Singapore	1
Slovakia	1
Sweden\|Australia\|France\|Italy\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Chile\|Colombia\|Croatia\|Czechia\|Egypt\|France\|Germany\|Greece\|India\|Israel\|Italy\|Japan\|Korea, Republic of\|Kuwait\|Lebanon\|Malaysia\|Mexico\|Netherlands\|Norway\|Philippines\|Poland\|Portugal\|Russian Federation\|Saudi Arabia\|Serbia\|Singapore\|Slovakia\|Slovenia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey	1
United States\|Argentina\|Australia\|Austria\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Czechia\|France\|Germany\|Hungary\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|New Zealand\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|China\|France\|Germany\|Greece\|Hungary\|India\|Israel\|Italy\|Japan\|Malaysia\|Mexico\|Netherlands\|Poland\|Russian Federation\|Slovakia\|South Africa\|Spain\|Thailand\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|Colombia\|Czechia\|Denmark\|Estonia\|France\|Germany\|Greece\|Hong Kong\|Hungary\|India\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Philippines\|Poland\|Portugal\|Romania\|Russian Federation\|Singapore\|South Africa\|Spain\|Sweden\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom\|Vietnam	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|Peru\|Chile\|China\|Czechia\|Denmark\|Estonia\|France\|Georgia\|Germany\|Greece\|Guatemala\|Hungary\|India\|Israel\|Italy\|Korea, Republic of\|Latvia\|Lithuania\|Mexico\|Netherlands\|New Zealand\|North Macedonia\|Norway\|Poland\|Portugal\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Bulgaria\|Canada\|France\|Germany\|Israel\|Italy\|Korea, Republic of\|Mexico\|Poland\|Portugal\|Russian Federation\|Serbia\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Canada\|France\|Italy\|Korea, Republic of\|Mexico\|Poland\|Romania\|Russian Federation\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Canada\|France\|Italy\|Korea, Republic of\|Poland\|Romania\|Russian Federation\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Canada\|Germany\|India\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Poland\|Russian Federation\|South Africa\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Chile\|Colombia\|Hong Kong\|Korea, Republic of\|Malaysia\|Mexico\|New Zealand\|Peru\|Philippines\|Puerto Rico\|Singapore\|Taiwan\|Thailand	1
United States\|Argentina\|Brazil\|Bulgaria\|Canada\|Colombia\|Czechia\|Germany\|Hungary\|India\|Korea, Republic of\|Malaysia\|Mexico\|Peru\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Slovakia\|Spain\|Taiwan\|Thailand\|Turkey\|Ukraine\|Vietnam	1
United States\|Argentina\|Brazil\|Canada\|China\|Denmark\|Germany\|Hungary\|India\|Japan\|Korea, Republic of\|Mexico\|Peru\|Philippines\|Poland\|Russian Federation\|Spain\|Sweden\|Ukraine\|United Kingdom\|Vietnam	1
United States\|Argentina\|Brazil\|Canada\|Colombia\|Germany\|Hungary\|Israel\|Italy\|Mexico\|Poland\|Romania\|Russian Federation\|South Africa\|Spain\|Ukraine	1
United States\|Argentina\|Brazil\|Canada\|Czech Republic\|France\|Italy\|Mexico\|Poland\|Puerto Rico\|Russian Federation\|Ukraine	1
United States\|Argentina\|Brazil\|Canada\|Czech Republic\|Germany\|Mexico\|Poland\|Puerto Rico\|Russian Federation\|Spain\|Ukraine	1
United States\|Argentina\|Brazil\|Colombia\|Germany\|Hungary\|Israel\|Italy\|Mexico\|Poland\|Romania\|Russian Federation\|South Africa\|Spain\|Ukraine	1
United States\|Argentina\|Brazil\|Germany\|Italy\|Korea, Republic of\|Mexico\|Poland\|Portugal\|Russian Federation\|Ukraine	1
United States\|Argentina\|India\|Korea, Republic of\|Malaysia\|Russian Federation\|Singapore\|Taiwan\|Turkey	1
United States\|Australia\|Austria\|Belgium\|Canada\|Czechia\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|Poland\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|Czechia\|France\|Germany\|Hungary\|Israel\|Italy\|Poland\|Russian Federation\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Poland\|Spain\|Switzerland	1
United States\|Australia\|Austria\|Belgium\|Czech Republic\|Denmark\|France\|Germany\|Greece\|Italy\|Netherlands\|Norway\|Poland\|Portugal\|Romania\|Spain\|Sweden\|Turkey\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Czech Republic\|France\|Germany\|Hungary\|Israel\|Italy\|Poland\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Czechia\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|Poland\|Russian Federation\|Spain\|Sweden	1
United States\|Australia\|Belgium\|Canada\|Finland\|France\|Germany\|Italy\|Norway\|Puerto Rico\|Sweden\|Switzerland\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|France\|Germany\|Greece\|Italy\|Netherlands\|Puerto Rico\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Canada\|Czechia\|Denmark\|France\|Germany\|Hungary\|Japan\|Korea, Republic of\|Norway\|Poland\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Canada\|Czechia\|Denmark\|France\|Germany\|Hungary\|Japan\|Korea, Republic of\|Poland\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Czech Republic\|Germany\|Italy\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Spain\|Taiwan\|United Kingdom	1
United States\|Australia\|Hong Kong\|Israel\|New Zealand\|Ukraine	1
United States\|Austria\|Belgium\|Canada\|Czechia\|Denmark\|Estonia\|France\|Germany\|Greece\|Hungary\|Italy\|Latvia\|Lithuania\|New Zealand\|Poland\|Portugal\|Russian Federation\|Spain\|Sweden\|Switzerland\|Turkey	1
United States\|Austria\|Belgium\|Croatia\|Czech Republic\|Germany\|Latvia\|Lithuania\|Poland\|Romania\|Russian Federation\|Serbia\|South Africa\|Ukraine\|United Kingdom	1
United States\|Belgium\|Canada\|Germany\|India\|Poland\|United Kingdom	1
United States\|Belgium\|Czechia\|France\|Germany\|Greece\|Hungary\|Italy\|Poland\|Russian Federation\|Ukraine	1
United States\|Belgium\|Germany\|Lithuania\|Poland\|United Kingdom	1
United States\|Brazil\|Canada	1
United States\|Brazil\|Hungary\|Mexico\|Poland\|Romania\|South Africa\|Spain\|Ukraine	1
United States\|Bulgaria\|Canada\|Georgia\|Germany\|Poland\|Ukraine	1
United States\|Bulgaria\|Croatia\|Czech Republic\|Germany\|Poland\|Romania\|Russian Federation\|Switzerland	1
United States\|Bulgaria\|Croatia\|Georgia\|Germany\|Hungary\|South Africa\|Ukraine\|United Kingdom	1
United States\|Bulgaria\|Czech Republic\|Germany\|Hungary\|Italy\|Poland\|Puerto Rico\|Romania\|United Kingdom	1
United States\|Bulgaria\|Czechia\|Hungary\|Poland\|Romania\|South Africa\|Spain	1
United States\|Bulgaria\|France\|Germany\|Italy\|Poland\|Romania\|Spain\|United Kingdom	1
United States\|Canada\|China\|Germany\|Japan\|Malaysia\|United Kingdom	1
United States\|Canada\|Denmark\|Germany\|Norway\|Sweden	1
United States\|Canada\|Germany	1
United States\|Canada\|Germany\|Russian Federation\|Spain	1
United States\|Canada\|Puerto Rico\|Taiwan	1
United States\|Canada\|United Kingdom	1
United States\|Cayman Islands	1
United States\|Chile	1
United States\|Croatia\|Czech Republic\|Denmark\|Georgia\|Hungary\|Italy\|Serbia\|Slovenia\|Ukraine	1
United States\|Czech Republic\|Denmark\|Germany\|Greece\|Italy\|Netherlands\|Portugal\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|France\|Germany\|Hungary\|Italy\|Lithuania\|Poland\|Spain	1
United States\|France\|Germany\|Lithuania\|Poland	1
United States\|France\|Spain\|United Kingdom	1
United States\|Germany	1
United States\|Germany\|Greece\|Italy\|Netherlands\|Poland\|Portugal\|Puerto Rico\|Spain\|Taiwan	1
United States\|Germany\|Puerto Rico\|United Kingdom	1
United States\|Germany\|United Kingdom	1
United States\|Guatemala	1
United States\|Hungary\|Lithuania\|Mexico\|Poland	1
United States\|United Kingdom	1
Vietnam	1

Site_count	Study_Count
1	626
2	68
3	24
4	26
5	17
6	7
7	11
8	5
9	5
10	6
11	10
12	9
13	6
14	5
15	9
16	4
17	3
18	7
19	5
20	6
21	6
22	2
23	1
24	2
25	3
26	4
27	2
28	7
29	1
30	4
31	4
32	3
33	4
34	2
35	2
36	4
37	1
38	4
39	4
40	3
41	2
42	1
43	2
44	2
45	3
47	2
49	2
50	2
51	2
52	2
53	4
55	2
56	1
57	2
58	1
59	1
60	2
61	1
62	2
64	1
66	2
68	1
69	1
71	1
72	3
73	3
76	1
83	1
84	1
85	1
89	2
90	2
91	2
98	1
105	2
106	3
107	1
110	1
114	2
115	2
118	2
123	1
124	1
125	1
138	1
141	1
145	1
157	1
169	1
170	1
183	1
184	1
192	1
196	1
203	1
209	1
229	1
231	1
239	1
249	1
278	1
342	1
360	1
381	1
398	1
439	1
465	1
503	1
602	1
754	1

Count of Versions	Count of Studies
1	96
2	123
3	121
4	134
5	91
6	75
7	43
8	45
9	45
10	30
11	20
12	13
13	12
14	11
15	13
16	9
17	11
18	8
19	8
20	7
21	11
22	6
23	10
24	2
25	5
26	1
27	3
28	3
29	2
30	5
31	2
32	2
33	3
34	5
35	1
36	1
37	5
38	1
39	1
42	2
43	2
44	2
45	1
46	1
47	2
50	1
51	1
52	1
53	1
54	2
57	1
62	1
63	1
64	2
69	1
70	1
71	1
73	1
77	1
78	1
80	1
83	1
91	1
92	1
95	1
97	1
116	1
119	1
120	2
135	1
139	1

Site_count	Study_Count
1	205
2	22
3	8
4	3
5	2
6	3
7	1
8	2
9	1
10	3
11	1
12	4
13	4
14	2
16	1
17	1
18	2
19	1
21	1
22	1
23	1
24	1
26	1
29	1
32	1
40	1
41	1
52	1
69	1
87	1
95	1
108	1

Count of Versions	Count of Studies
1	50
2	43
3	42
4	26
5	27
6	21
7	9
8	6
9	8
10	8
11	5
12	6
13	2
14	1
15	1
16	1
17	4
18	2
21	1
22	2
24	2
28	1
30	1
31	2
37	2
39	1
53	1
54	2
56	1
59	1
79	1

Site_count	Study_Count
1	626
2	68
3	24
4	26
5	17
6	7
7	11
8	5
9	5
10	6
11	10
12	9
13	6
14	5
15	9
16	4
17	3
18	7
19	5
20	6
21	6
22	2
23	1
24	2
25	3
26	4
27	2
28	7
29	1
30	4
31	4
32	3
33	4
34	2
35	2
36	4
37	1
38	4
39	4
40	3
41	2
42	1
43	2
44	2
45	3
47	2
49	2
50	2
51	2
52	2
53	4
55	2
56	1
57	2
58	1
59	1
60	2
61	1
62	2
64	1
66	2
68	1
69	1
71	1
72	3
73	3
76	1
83	1
84	1
85	1
89	2
90	2
91	2
98	1
105	2
106	3
107	1
110	1
114	2
115	2
118	2
123	1
124	1
125	1
138	1
141	1
145	1
157	1
169	1
170	1
183	1
184	1
192	1
196	1
203	1
209	1
229	1
231	1
239	1
249	1
278	1
342	1
360	1
381	1
398	1
439	1
465	1
503	1
602	1
754	1

Count of Versions	Count of Studies
1	96
2	123
3	121
4	134
5	91
6	75
7	43
8	45
9	45
10	30
11	20
12	13
13	12
14	11
15	13
16	9
17	11
18	8
19	8
20	7
21	11
22	6
23	10
24	2
25	5
26	1
27	3
28	3
29	2
30	5
31	2
32	2
33	3
34	5
35	1
36	1
37	5
38	1
39	1
42	2
43	2
44	2
45	1
46	1
47	2
50	1
51	1
52	1
53	1
54	2
57	1
62	1
63	1
64	2
69	1
70	1
71	1
73	1
77	1
78	1
80	1
83	1
91	1
92	1
95	1
97	1
116	1
119	1
120	2
135	1
139	1

Site_count	Study_Count
1	205
2	22
3	8
4	3
5	2
6	3
7	1
8	2
9	1
10	3
11	1
12	4
13	4
14	2
16	1
17	1
18	2
19	1
21	1
22	1
23	1
24	1
26	1
29	1
32	1
40	1
41	1
52	1
69	1
87	1
95	1
108	1

Count of Versions	Count of Studies
1	50
2	43
3	42
4	26
5	27
6	21
7	9
8	6
9	8
10	8
11	5
12	6
13	2
14	1
15	1
16	1
17	4
18	2
21	1
22	2
24	2
28	1
30	1
31	2
37	2
39	1
53	1
54	2
56	1
59	1
79	1

renal insufficiency, chronic

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Site_count	Study_Count
1	626
2	68
3	24
4	26
5	17
6	7
7	11
8	5
9	5
10	6
11	10
12	9
13	6
14	5
15	9
16	4
17	3
18	7
19	5
20	6
21	6
22	2
23	1
24	2
25	3
26	4
27	2
28	7
29	1
30	4
31	4
32	3
33	4
34	2
35	2
36	4
37	1
38	4
39	4
40	3
41	2
42	1
43	2
44	2
45	3
47	2
49	2
50	2
51	2
52	2
53	4
55	2
56	1
57	2
58	1
59	1
60	2
61	1
62	2
64	1
66	2
68	1
69	1
71	1
72	3
73	3
76	1
83	1
84	1
85	1
89	2
90	2
91	2
98	1
105	2
106	3
107	1
110	1
114	2
115	2
118	2
123	1
124	1
125	1
138	1
141	1
145	1
157	1
169	1
170	1
183	1
184	1
192	1
196	1
203	1
209	1
229	1
231	1
239	1
249	1
278	1
342	1
360	1
381	1
398	1
439	1
465	1
503	1
602	1
754	1

Count of Versions	Count of Studies
1	96
2	123
3	121
4	134
5	91
6	75
7	43
8	45
9	45
10	30
11	20
12	13
13	12
14	11
15	13
16	9
17	11
18	8
19	8
20	7
21	11
22	6
23	10
24	2
25	5
26	1
27	3
28	3
29	2
30	5
31	2
32	2
33	3
34	5
35	1
36	1
37	5
38	1
39	1
42	2
43	2
44	2
45	1
46	1
47	2
50	1
51	1
52	1
53	1
54	2
57	1
62	1
63	1
64	2
69	1
70	1
71	1
73	1
77	1
78	1
80	1
83	1
91	1
92	1
95	1
97	1
116	1
119	1
120	2
135	1
139	1

Site_count	Study_Count
1	205
2	22
3	8
4	3
5	2
6	3
7	1
8	2
9	1
10	3
11	1
12	4
13	4
14	2
16	1
17	1
18	2
19	1
21	1
22	1
23	1
24	1
26	1
29	1
32	1
40	1
41	1
52	1
69	1
87	1
95	1
108	1

Count of Versions	Count of Studies
1	50
2	43
3	42
4	26
5	27
6	21
7	9
8	6
9	8
10	8
11	5
12	6
13	2
14	1
15	1
16	1
17	4
18	2
21	1
22	2
24	2
28	1
30	1
31	2
37	2
39	1
53	1
54	2
56	1
59	1
79	1